Endocrine Abstracts

Context: The impact of abnormal cortisol secretion on cognitive functions in patients with mild autonomous cortisol secretion (MACS) remains uncertain.Objective: To assess cognitive functions, determine serum brain-derived neurotrophic factor (BDNF) concentration in patients with MACS, and investigate the possible association between cognitive subdomains and BDNF after minimizing the impact of body mass index (BMI) and visceral adiposity.<p class="ab...

Background: Adrenal venous sampling (AVS) is the gold standard diagnostic approach for differentiating unilateral from bilateral primary aldosteronism (PA). However, it is a costly, invasive, and operator-dependent procedure with restricted availability.Objectives: It was aimed to develop a prediction model based on a simple clinical score with prominent parameters from the current literature for the subtype diagnosis of PA. The contribution of adrenal v...

Purpose: The liver is known to be protected from steatosis under the influence of high GH/IGF-1. Cytokeratin 18 (CK18) and insulin-like growth factor binding protein 7 (IGFBP7) increase in liver steatosis and fibrosis. Whether decreasing lipid content completely protects the liver from metabolic alterations and the response of CK18 and IGFBP7 to liver changes in acromegaly is unknown.Methods: This single-center, multidisciplinary, cross-sectional study i...